![]() Once thought of as the disease of kings, gout has a prevalence of 3.9% in the US, affecting 8.3 million adults, 1, 2 with a doubling of incidence seen in both men and women over the past 20 years. ![]() Gout is a chronic and often debilitating disease associated with recurrent flares of inflammatory arthritis, manifesting as severe pain and joint dysfunction, which, if untreated, can lead to joint damage and significant morbidity. In this review, we explore the potential benefits of cherries and cherry products as a nonpharmacologic option for the treatment of gout. Based on these properties, cherries may reduce both the acute and chronic inflammation associated with recurrent gout flares and its chronic destructive arthropathy. Perhaps a quarter of patients with gout try cherries or cherry products to treat their gout, which have antioxidant and anti-inflammatory (IL-6, TNF-α, IL-1β, IL-8, COX-I and -II) properties, hypouricemic effects, and the ability to downregulate NFkB-mediated osteoclastogenesis. The cherry is a small nutrient-rich fruit that has garnered a great deal of attention in recent years as a nonpharmacologic option for the treatment of a multitude of disease manifestations. Patients with gout often have a multitude of comorbidities, leading to concern over drug–drug interactions and medication adverse events. Despite the availability of effective urate-lowering therapy (ULT) and anti-inflammatory drugs for the treatment of gout, there is considerable interest in novel treatment approaches.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |